Manufacturer: AJANTA PHARMA
Category: Erectile dysfunction
Substance: sildenafil citrate
Package: 100 mg/tab.
Viagra (sildenafil) is used for the treatment of erectile dysfunction. It is a phosphodiesterase-5 (PDE5) inhibitor. Side effects of Viagra (sildenafil) include warmth or redness in the face, neck, or chest; stuffy nose; headaches, stomach pain, nausea, diarrhea, and an inability to differentiate between the colors green and blue. Loss of hearing, ringing in the ears and dizziness are other potential side effects.
Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.
Assess the tolerability and efficacy of sildenafil initiated at the 100-mg dose in men with ED.
Men with ED (score < or =25 on the Erectile Function domain of the International Index of Erectile Function) who had received < or =6 total doses of a phosphodiesterase type 5 inhibitor and none within 4 weeks were randomized to 8 weeks of double-blind, placebo-controlled (DBPC), fixed-dose treatment (50 or 100 mg sildenafil or placebo) followed by 4 weeks of open-label flexible-dose sildenafil (50 or 100 mg).
Action Mechanisam of Sildenafil Citrate
The major reason behind erectile dysfunction is the less blood flowing to the male organ. Sildenafil citrate is used to correct the blood flow. As mentioned earlier health issues, penile surgery or stress affects blood flowing to the male organ. Another reason for the same is the effect of an enzyme named PDE5 on the arteries. This enzyme affects the smooth cell lining of arteries and constricts them. This is how blood flow gets reduced.
Sildenafil citrate works on this enzyme. It blocks it successfully to reduce its concentration in the penile area. On the hander it also increases the level of cyclic GMP which relaxes the blood vessels. Because of this chemical, these arteries become flexible and wide enough to carry blood. More blood reaches to the male organ within short time span. This is how sildenafil citrate helps in gaining tight and firm erection.
This whole process of blocking the PDE5 enzyme and augmenting cyclic GMP in the penile region takes few minutes. To initiate the procedure, erotic stimulation is needed. That is why after consuming sildenafil citrate, getting involved in the carnal activity is needed. Erection develop by the pill remain for longer time span. It stays for four hours.