Category: Post Cycle Therapy (PCT)
Package: 25 mg/tab. (100 tab.)
Proviron (mesterolone) is an interesting anabolic steroid, though it is not of much value to bodybuilding. It seems that the most common reason for many to consider including it in a steroid stack is for anti-estrogenic activity. In the days before anti-aromatases and the use of SERMs (selective estrogen receptor modulators) such as Clomid and Nolvadex, there was some merit to this.
An amount of aromatizing steroid marginally over the amount that would be tolerable without Proviron became tolerable with the inclusion of it. However, the effect is indeed only marginal, and much better anti-estrogenic agents now exist. When these are used, there is no need for Proviron as an anti-estrogen.
The mechanism by which it has some effectiveness in this regard is from binding weakly to the estrogen receptor without activating it, and to the aromatase enzyme. In the first case, this partially reduces the number of receptor sites momentarily available to bind estrogen, thus reducing estrogenic activity. In the second case, some fraction of aromatase molecules at any given moment are unavailable to bind and convert testosterone, their binding sites being occupied with mesterolone.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone, The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to potentate the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an antiestrogen. It is believed to act as an antiaromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. A related disadvantage to Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia and water retention. Most athletes actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly minimized.
Androgens are not suitable for enhancing muscular development in healthy individuals or for increasing physical ability (See Adverse Effects).
The diagnosis of hypogonadism in males requires full endocrinological assessment including clinical history and physical examination, expert interpretation of serial measurements of serum testosterone, LH and FSH, additional tests as required to identify underlying disorders, and evaluation of the general health of the patient. See Dosage and Administration.
Prostate disease should be excluded prior to commencement, and regular examinations of the prostate should be carried out prophylactically.
Hepatic impairment (monitoring of hepatic function is recommended).
Conditions aggravated by fluid overload from sodium or fluid retention, such as cardiovascular disorders or renal impairment, hypertension, epilepsy or migraine.
In older men, urinary obstruction may be precipitated. Increased libido may occur.
Use in puberty may cause premature closure of the epiphyses and stop linear growth.
Diabetes mellitus, androgen-sensitive polycythaemia or sleep apnoea may be exacerbated.
Androgens are considered to be unsafe in patients with porphyria.
In rare cases benign and in even rarer cases malignant liver tumours leading in isolated cases to life-threatening intra-abdominal haemorrhage have been observed after the use of hormonal substances such as the one contained in Proviron. Peliosis hepatis has been reported in patients who received high doses over a prolonged period. Upper abdominal complaints should be reported to the doctor.