T3 (liothyronine – T3)

T3 (liothyronine - T3)

Manufacturer: GENESIS
Category: Oral steroids
Substance: liothyronine (T3)
Package: 50 mcg/tab. (100 tab.)

Lionine – T3 (Tiromel), brand name for substance liothyronine sodium is a thyroid hormone. It is used to treat thyroid insufficiency (hypothyroidism). Taking of T3 causes a faster conversion of carbohydrates, proteins, and fats. Body builders are especially interested in an increased lipolysis, which means increased fat burning and use it during the weeks before an event without hunger diet. Combination of T3 and Clenbuterol is one of the most popular fat burning stacks and it will burn an enormous amount of fat in a short time of period.

Obesity is a chronic metabolic disease, which is considered apublic health problem that may lead to insulin resistance andincreased serum leptin levels, affecting both developed andemerging countries [1]. It may be caused by several differentfactors, especially the increased availability and consumption ofhighly palatable diets as well as low energy expenditure [2].Obesity causes an increase in the production of reactive oxygenspecies (ROS) [3], leading to redox system imbalance andconsequently an oxidative stress state. Such a state causes damageto lipids, proteins and especially DNA [4]. The literature thuspresents several strategic approaches to deal with obese individ-uals, including food restriction and physical exercise [5]. Theadministration of thyroid hormones, alone or in combination witha hypocaloric diet, occurs illicitly despite the fact that it is notaccepted as an obesity treatment by federal health agencies.Thyroid hormones are involved in the regulation of energyexpenditure and thermogenesis. Thyroid dysfunction is oftenassociated with changes in appetite and body weight as well as adecrease in both insulin resistance and serum leptin concentration[6]. However, it is not known yet if supraphysiological doses ofthyroid hormones together with either obesity or a calorierestriction diet might increase DNA damage, oxidative stress,insulin resistance and serum leptin concentration. The objective ofour study was to determine the effects of a supraphysiological doseof T3on both obese and calorie-restricted obese rats by assessingtheir DNA damage and oxidative stress.

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