Use of tablets clomiphene for infertility

Use of tablets clomiphene for infertilityThe use of tablets clomiphene for infertility

Female infertility today – a very common phenomenon. The first thing that doctors are making in the treatment of infertility in women – a course of treatment drugs, which should stimulate the production of sufficient amounts of certain hormones that ovulation has occurred. The modern pharmaceutical industry today offers a wide range of products aimed at the stimulation of ovulation in women with one of these drugs can be called clomiphene.

Instructions for use

These tablets are antiestrogen which has a non-steroidal structure. Its action is to bind with the estrogen receptors of the pituitary and ovary.

If the body decreased levels of estrogen, the drug Alphabolin (methenolone enanthate)will produce a normal estrogenic effect, and if the level is much higher than normal – anti-estrogen effect.

When you receive a small dose of the drug increases the secretion of gonadotropins, triggers ovulation. But in large doses, on the contrary, it inhibits the production of gonadotropins.

In addition, this drug is capable of preventing the occurrence of various side effects caused by the use of steroids in athletes.

Most often clomiphene is assigned a doctor in the following cases:

  • infertility caused by the absence of ovulation;
  • aminoreya in different forms;
  • galactorrhea, the cause of which is a tumor of the pituitary;
  • metrorrhagia;
  • polycystic ovary syndrome;
  • androgen deficiency;
  • oligospermia;
  • violation of gonadotropic pituitary function.

The tablets are taken only inside.

To stimulate the beginning of ovulation, your doctor may prescribe 50 mg clomiphene before bed for five days. Starting a course of the drug should be the fifth day of the menstrual cycle. If there are no monthly, then start taking clomiphene can be any day.

The course of treatment with clomiphene ended, and tablets did not give the desired effect (ovulation has not occurred during the 30 days of the end of treatment), then the dose can be increased to 150 mg 1 time per day, or a course of treatment is extended to 10 days. The total dose of clomiphene for the full course of treatment should not be more than 1 year About the fact that ovulation has taken place, can tell biphasic basal temperature or menstrual bleeding, if a woman suffers amenorrhea.

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If ovulation has been, and still pregnancy does not occur, it will be necessary to repeat the course of drug treatment in the same dosages.

If the alleged ovulation on certain days there is no menstrual bleeding, it can be a reason to assume that the pregnancy. Therefore, it is very important before starting the next course of treatment with clomiphene confirm the presence or absence of pregnancy or her. This can be done only by the attending gynecologist.

The tablets may be administered to men and 1-2 times a day in a dosage of 50 mg. The treatment will last 3-4 months, you will need to periodically monitor the sperm.

During treatment with clomiphene are possible side effects from these systems and organs:

Nervous System: headache, frequent dizziness, somnolence, insomnia, slow reaction, depression, increased anxiety;

digestive system: vomiting, nausea, flatulence, diarrhea;

urogenital system: abdominal pain, frequent urination, dysmenorrhea, increased ovarian size, polyuria, the presence of multiple pregnancy;

Allergic reactions: rash, dermatitis (such side effects are rare);

Other adverse reactions of the body: increased body Injectable steroidsweight, frequent hot flashes, breast tenderness, blurred vision, abdominal pain, pain in the male testicles, hair loss.

In the event of any of these events or symptoms of ovarian hyperstimulation, it is necessary to reduce the dosage or completely cancel the course of drug treatment. Make it should only doctor.

Omitting receiving regular doses of clomiphene, you need as quickly as possible to see a doctor. Before beginning treatment and at the time it must be constantly observed at the gynecologist. He must control the normal functioning of the ovaries, as well as to carry out vaginal repetition. If cysts or ovaries were detected strongly increased, treatment with clomiphene should be temporarily suspended until such time as the ovaries are unable to return to its normal size. Only the course can continue after this treatment, but the dose will be minimal or therapy time will be shorter. During the course of treatment with clomiphene also need to monitor liver function.

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The tablets are well absorbed by the digestive tract, and then is metabolized in the liver, they are excreted in the bile. The drug passes enterohepatic recycling. Half-life of the drug from the body is 5-7 days intestine with feces.

Clomiphene is compatible with drugs gonadotropins. Pills increase the likelihood of multiple pregnancies, as the attending physician must inform the patient before treatment.

The most effective drug to be at a normal level of endogenous estrogen, and practically has no effect if the pituitary gonadotropic hormone at a low concentration.

When receiving clomiphene should be extremely careful while driving the vehicle and occupation of such activities that require quick reaction and attention.

Tablets should be stored in a dark place where the temperature does not exceed 25 degrees. The permissible storage life of the drug is 36 months.


As described in the instructions clomiphene not be given in the following cases:

  • pregnancy;
  • hypersensitivity to the drug;
  • ovarian cyst;
  • endometriosis;
  • pituitary tumor;
  • hepatic or renal insufficiency;
  • the tendency to form blood clots;
  • uterine bleeding, which in no way associated with ovulation;
  • metrorrhagia;
  • ovarian failure.


Now a lot of stores that offer a variety of products for athletes. In these stores you can find and clomiphene. But we should be cautious and buy only quality products in proven areas.

Comparative table of prices of clomiphene online stores, rub.

The drug during pregnancy

If there is a pregnancy, that should confirm or refute the doctor, the drug is contraindicated, as specified in the instructions for use of clomiphene. Also, the drug is contraindicated during lactation.

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Active ingredients

Clomiphene is available in tablet form. It can be packaged in a contour with cells or a bank of 10 tablets as well as in a cardboard bundle by 1,2,3 or 4 of packing or in the bank.

One Clomiphene tablet contains:

  • clomiphene citrate – 0.05 g
  • other auxiliary ingredients: lactose, potato starch, gelatin, magnesium stearate, talc.

Overdose of the drug

The maximum permissible dose

Clomiphene – a tablet for oral administration. Drink no matter when the food was taken.

  • Women for ovulation induction – 50 mg 1 time a day for 5 days before going to bed (course start from the fifth day of the menstrual cycle);
  • Women, if ovulation has not occurred within 30 days of receiving the drug – 150 mg 1 time a day at bedtime for 5 days, or extend the course of treatment (only 10 days);
  • Men in the treatment of oligospermia – 1-2 times a day 50 mg for 3-4 months.

Symptoms of overdose

If the drug is taken in dosages that far exceed the dosage prescribed by the attending physician, these symptoms may occur:

In case of cancellation of the drug, must go through the unpleasant symptoms themselves.

Clomiphene is highly effective in the treatment of infertility in women, but to begin a course of therapy is possible only after the correct diagnosis and the treating physician.

This information is provided solely for information. It is important to remember that the uncontrolled intake of any drug may have the most dire consequences. To avoid this, before you start taking any drug, it is necessary to consult a gynecologist, because the body of each person is different.